Tuberculosis Drug Information Guide, 2nd edition was created through a collaboration of the Curry International Tuberculosis Center (CITC) and the State of California Department MYAMBUTOL (ethambutol hydrochloride) 100 and 400 mg tablets contain the following inactive ingredients: Gelatin, Hydroxypropyl Methylcellulose, Magnesium Stearate, Sodium Lauryl Sulfate, Sorbitol, Stearic Acid, Sucrose, Titanium Dioxide and other ingredients. 10 mg/kg/dose (Max: 600 mg/dose) given PO or IV once daily or 2, 3, or 5 times per week. The usual initial treatment regimen is isoniazid plus pyrazinamide, ethambutol, and rifampin administered once daily or 5 times per week DOT for 2 months; once daily or 5 times per week DOT for 2 weeks, then 2 times per week for 6 weeks; or 3 times per week. Ocular Toxicity of Ethambutol Introduction Ethambutol hydrochloride is one of the first line agents employed in the treatment of tuberculosis, which remains Drug Information Center/KAUH Drug Dosing in Obesity Maintenance doses should be based on ideal body weight, conventional daily doses with adjustments based upon Detailed dosage guidelines and administration information for Biaxin (clarithromycin). Includes dose adjustments, warnings and precautions. NDA 204-384 Deputy Division Director Summary Review_____5 These changes appeared to be dose and duration related. Gout can be defined as arthritis due to deposition of monosodium urate (MSU) crystals within joints causing acute inflammation and eventual tissue damage. The duration and magnitude of hyperuricaemia is directly correlated with the likelihood of developing gouty arthritis and developing uric acid kidney stones. Renal Impairment. The following antibiotics may require dose adjustment in patients with reduced renal function. Recommendations are based on creatinine clearance (CrCl), which is an estimate of renal function (GFR). The advice on dosing in renal impairment linked from this page has mainly been taken from the Renal Drug Handbook 3rd edition. Every effort has been made to ensure accuracy and that the best information available has been used.